![]() Recent high-resolution structures of cocrystals of triple-helical peptides (THPs) bound to collagen partners have confirmed well-established principles of protein interactions and also shown a diversity of binding modes. The increasing number of receptors and ligands found to bind to collagen during normal biological processes or in pathological conditions raises questions about the specificity and nature of binding to this triple-helical protein. 4 OSCAR is an osteoclast-associated receptor, and its activation by collagen costimulates the Fc receptor common γ-chain, inducing immunoreceptor tyrosine-based activation motif signaling pathways for osteoclastogenesis. 3 LAIR-1, expressed on most immune cells, is an inhibitory receptor involved in reducing signals from activating receptors. GPVI, expressed at platelet surfaces, is involved in platelet adhesion to subendothelial collagen and subsequent activation. The genes of these 3 receptors are found in the LRC, and all 3 have extracellular ligand-binding immunoglobulin-like domains which may come in contact with collagen following inflammation or tissue damage. Among proteins which interact with collagens are 3 members of the immunoglobulin superfamily of receptors: GPVI, LAIR-1, and OSCAR. A schematic diagram of the collagen interactome (see figure 2) illustrates the different categories of molecules which bind collagen, including its involvement with other ECM and plasma proteins, its interactions with enzymes during biosynthesis, and its binding to receptors which trigger cell signaling. In addition to its structural properties, collagen plays important biological roles in the extracellular matrix (ECM). 2 Close modalĬollagen forms rodlike triple-helical molecules which assemble into cross-linked fibrils that provide mechanical strength to tissues. The central electron micrograph of collagen fibrils is from Gross and Schmitt. BMP, bone morphogenetic protein BSP, bone sialoprotein DDR, discoidin domain receptor GAG, glycoaminoglycan GPVI, glycoprotein VI HSP, heat shock protein HYAL, hyaluronidase LAIR-1, leukocyte-associated immunoglobulin-like receptor-1 LOX, lysyl oxidase LRC, leukocyte receptor complex MMP, matrix metalloproteinase PCPE, procollagen C-proteinase enhancer PDGF, platelet-derived grwoth factor PEDF, pigment epithelium-derived factor PG, proteoglycan SPARC, secreted protein acidic and rich in cysteine THBS, thrombospondins VWF, von Willebrand factor. Molecules connected to collagen by solid lines indicate that the structures of cocrystals of that molecule (or part of that molecule) with a collagen-like peptide have been solved. ![]() A gray outline around the molecule name indicates the crystal structure of the molecule has been determined. 2Ī schematic diagram of the interaction network of major fibrillar collagens showing the classes of molecules that interact with them, together with representative examples of each class (plotted with Cytoscape 3.2.1, based on multiple sources including MatrixDB ). ![]() * cy.A schematic diagram of the interaction network of major fibrillar collagens showing the classes of molecules that interact with them, together with representative examples of each class (plotted with Cytoscape 3.2.1, based on multiple sources including MatrixDB ). Now, how do I have to go about if I wanted to show a new graph consisting of the selected nodes and edges when right-clicking on one of the already selected nodes?Ĭontainer: document.getElementById('cy'), I have a graph ( source credit) where I can select a (or multiple) node(s) and its connected edges (the edges turn blue when I select a node).
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